Recent Patents on Anti-Cancer Drug Discovery A Prooxidant Mechanism for the Anticancer and Chemopreventive Properties of Plant PolyphenolsĬurrent Drug Targets Antibody-Dependent Cell-Mediated Cytotoxicity Through Natural Killer Gene Expression Signatures of Lymph Node Metastasis in Oral Cancer: Molecular Characteristics and Clinical SignificancesĬurrent Cancer Therapy Reviews Donepezil Derivatives Targeting Amyloid-β Cascade in Alzheimer's DiseaseĬurrent Alzheimer Research The Dual Role of Nitric Oxide in GliomaĬurrent Pharmaceutical Design Epigenetic Modulation Using Small Molecules - Targeting Histone Acetyltransferases in DiseaseĬurrent Medicinal Chemistry The Use of Cytokines and Chemokines in the Cancer Immunotherapy State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 200437,ChinaĪbstract: Traditional Chinese Medicines (TCMs), particularly the Chinese herbal medicines, are valuable.Title:The Role of Traditional Chinese Herbal Medicines and Bioactive Ingredients on Ion Channels: A Brief Review and ProspectĪuthor(s): Yian Huang, Shumei Ma, Yan Wang, Renjie Yan, Sheng Wang, Nan Liu, Ben Chen, Jia Chen and Li Liu* Keywords: Traditional chinese medicine, potassium channel, calcium channel, ion channels, single chemical entity, ethnomedicines. Recently available scientific evidences for TCMs and related bioactive compounds that haveīeen reported with the modulatory effects on different ion channels, and thus provides a new ethnopharmacologicalĪpproach to understand the usage of TCMs. Research papers confirming their effects on ion channels are discussed in this review. (iv) Only those TCM herbs with more than 5 (ginger) and Cannabis sativa (marijuana) are excluded. (iii) Those most famous herbal medicines like Capsicum annuum (pepper), Curcuma longa (ii) The majorĭiscussions in this review focus on single TCM agent and the herbal formulas are only discussedįor a little. (i) Only the herbal materialsĪre included in this review and the animal- and mineral-original TCMs are excluded. The following conditions are used to limit the range of our review. Their regulatory effects on different ion channels including Ca2+, K+, Na+, Cl- channels and TRP, P2X The studies of TCM and their containing bioactive compounds, and attempt to provide an overview for Of TCMs developed rapidly to understand the scientific basis of these herbs. Herbal formulas like Jingshu Keli, Wenxin Keli and Danzhen powder. Single drug agent like Salvia miltiorrhiza, Ligusticum chuanxiong and Angelica sinensis, and those Sources of medicines and have been used for centuries. Traditional Chinese Medicines (TCMs), particularly the Chinese herbal medicines, are valuable
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